Women who inject drugs and violence: Need for an integrated response. / Mujeres que usan drogas inyectadas y violencia: Necesidad de una respuesta integrada.

The aim of this study was to describe the prevalence of physical and/or sexual violence experienced by women who inject drugs (WWID) and identify associated factors. A cross-sectional study was conducted among 120 WWID in a network of harm reduction centres using an anonymous questionnaire. Oral fluid samples were also collected to estimate the prevalence of HIV and hepatitis C. Univariate and multivariate Poisson regression models with robust variance were performed to identify the factors associated with experiencing violence, obtaining prevalence ratios (PR) and their 95% confidence intervals. The results showed that the prevalence of violence reported by WWID in the last 12 months was 45.8% (42.2% physical and 11.9% sexual aggression). In multivariate analysis, variables associated with experiencing violence were homelessness (PR = 1.59; CI: 1.07-2.38), reporting exchanges of sex for money or drugs (PR = 1.65; CI: 1.19-2.29), reporting a previous sexually transmitted infection (PR = 1.49; CI: 1.04-2.15) and/or injecting drugs less frequently than daily (RP = 2.29; CI: 1.49-3.54). This study highlights the importance of establishing detection protocols and systems of referral to the network of attention to women suffering violence, within the centres of the drug addiction care network, as well as the development of multilevel strategies that take into account not only individual factors but also other social and/or structural aspects that may be playing a relevant role in addressing this problem.

El objetivo de este estudio fue describir la prevalencia de violencia física y/o sexual experimentada por mujeres que usan drogas por vía inyectada (MUDVI) e identificar factores asociados. Se realizó un estudio transversal en 120 MUDVI usuarias de centros de reducción de daños mediante un cuestionario anónimo y recogida de muestras de fluido oral para estimar la prevalencia del VIH y de la hepatitis C. Los factores asociados a la presencia de violencia se analizaron mediante un modelo de regresión de Poisson con varianza robusta univariante y multivariante, obteniendo razones de prevalencia (RP) y sus intervalos de confianza al 95%. Los resultados muestran que la prevalencia de  agresiones en los últimos 12 meses fue del 45,8% (42,2% agresiones físicas y 11,9% agresiones sexuales). A nivel multivariante, las variables asociadas a la presencia de violencia fueron estar sin domicilio fijo (RP=1,59; IC: 1,07-2,38), ejercer el trabajo sexual (RP=1,65; IC: 1,19-2,29), haber sufrido alguna infección de transmisión sexual (RP=1,49; IC: 1,04-2,15) y/o inyectarse drogas no de forma diaria (RP=2,29; IC: 1,49-3,54). Este estudio pone de manifiesto la importancia de establecer protocolos de detección, y derivación a la red de atención a la violencia de género, dentro de los centros de la red de atención a las drogodependencias, así como el desarrollo de estrategias multinivel que tengan en cuenta no solamente factores individuales sino también otros aspectos sociales y/o estructurales que pueden estar jugando un papel relevante a la hora de abordar este problema.

Mujeres que usan drogas inyectadas y violencia: Necesidad de una respuesta integrada / Women who inject drugs and violence: Need for an integrated response

El objetivo de este estudio fue describir la prevalencia de violenciafísica y/o sexual experimentada por mujeres que usan drogas porvía inyectada (MUDVI) e identificar factores asociados. Se realizó unestudio transversal en 120 MUDVI usuarias de centros de reducción dedaños mediante un cuestionario anónimo y recogida de muestras defluido oral para estimar la prevalencia del VIH y de la hepatitis C. Losfactores asociados a la presencia de violencia se analizaron medianteun modelo de regresión de Poisson con varianza robusta univariante ymultivariante, obteniendo razones de prevalencia (RP) y sus intervalosde confianza al 95%. Los resultados muestran que la prevalencia de agresiones en los últimos 12 meses fue del 45,8% (42,2% agresionesfísicas y 11,9% agresiones sexuales). A nivel multivariante, las variablesasociadas a la presencia de violencia fueron estar sin domicilio fijo(RP=1,59; IC: 1,07-2,38), ejercer el trabajo sexual (RP=1,65; IC: 1,19-2,29), haber sufrido alguna infección de transmisión sexual (RP=1,49;IC: 1,04-2,15) y/o inyectarse drogas no de forma diaria (RP=2,29;IC: 1,49-3,54). Este estudio pone de manifiesto la importancia deestablecer protocolos de detección, y derivación a la red de atencióna la violencia de género, dentro de los centros de la red de atencióna las drogodependencias, así como el desarrollo de estrategiasmultinivel que tengan en cuenta no solamente factores individualessino también otros aspectos sociales y/o estructurales que puedenestar jugando un papel relevante a la hora de abordar este problema. (AU)

The aim of this study was to describe the prevalence of physical and/or sexual violence experienced by women who inject drugs (WWID)and identify associated factors. A cross-sectional study was conductedamong 120 WWID in a network of harm reduction centres using ananonymous questionnaire. Oral fluid samples were also collectedto estimate the prevalence of HIV and hepatitis C. Univariate andmultivariate Poisson regression models with robust variance wereperformed to identify the factors associated with experiencingviolence, obtaining prevalence ratios (PR) and their 95% confidenceintervals. The results showed that the prevalence of violence reportedby WWID in the last 12 months was 45.8% (42.2% physical and 11.9%sexual aggression). In multivariate analysis, variables associated withexperiencing violence were homelessness (PR = 1.59; CI: 1.07-2.38),reporting exchanges of sex for money or drugs (PR = 1.65; CI: 1.19-2.29), reporting a previous sexually transmitted infection (PR =1.49; CI: 1.04-2.15) and/or injecting drugs less frequently than daily(RP = 2.29; CI: 1.49-3.54). This study highlights the importance ofestablishing detection protocols and systems of referral to the networkof attention to women suffering violence, within the centres of thedrug addiction care network, as well as the development of multilevelstrategies that take into account not only individual factors but alsoother social and/or structural aspects that may be playing a relevantrole in addressing this problem. (AU)

The urban environment of alcohol: a study on the availability, promotion and visibility of its use in the neighborhoods of Barcelona. / Entorno urbano de alcohol: un estudio sobre disponibilidad, promoción y visibilidad del consumo en barrios de Barcelona.

INTRODUCTION: This paper describes the presence of alcohol in the public space, assessing establishments that offer it, its advertising, and signs of consumption, as factors that may influence its consumption. METHOD: Descriptive observational study based on cluster sampling with two-step selection. Results are described, and the spatial association between variables is assessed. RESULTS: In the 20 census tracts studied, 306 premises were identified that offered alcoholic beverages: 204 were on-premises and 102 were off-premises, mainly supermarkets and food retail stores. Their spatial distribution was uneven, concentrated in two central districts. We identified 72 publicity items, mostly sponsorship of musical events. There were many promotional items linked to on- premises, especially in their terraces. Five people were detected promoting consumption or selling alcohol in the Old Town. In each time slot, between 39 and 51 signs of consumption on the public space were observed (mostly abandoned beer cans), more frequent at night and in the Old Town. There is an association between the presence of establishments that offer alcohol and advertising. There is no relationship between these variables and signs of consumption in the public space; these are concentrated in the Old Town, which has greater presence of tourism. CONCLUSIONS: The urban environment is characterized by elements that stimulate alcohol use and its distribution is uneven, with a strong influence of tourism-related activities. Further regulation of alcohol promotion, availability and consumption in the public space may change its social image and decrease its use.

Introducción. Se describe la presencia de alcohol en el espacio público, valorando los establecimientos que lo ofrecen, la publicidad, y los indicios de consumo, como factores que pueden inducir el consumo. Método. Estudio observacional descriptivo basado en un muestreo por conglomerados con selección bietápica. Se describen los resultados, y se valora la asociación espacial entre variables. Resultados. En las 20 secciones censales estudiadas se identificaron 306 establecimientos que ofrecían bebidas alcohólicas: 204 de venta y consumo y 102 de venta sin consumo, básicamente supermercados y comercio alimentario. Su distribución territorial fue desigual, concentrada en dos distritos céntricos. Se identificaron 72 elementos de promoción y publicidad destacando el patrocinio de actividades musicales. Se observan elementos promocionales vinculados a los locales de venta y consumo, sobre todo en sus terrazas. Se detectaron cinco personas realizando venta ambulante o promoción del consumo en el casco antiguo. En cada franja horaria se apreciaron entre 39 y 51 indicios de consumo en la vía pública (mayoritariamente envases de cerveza abandonados), más frecuentes de noche y en el casco antiguo. Hay una asociación entre la presencia de establecimientos que ofrecen alcohol y la de elementos de publicidad. No se aprecia relación entre estas variables y los indicios de consumo en el espacio público; éstos se concentran en el casco antiguo, con mayor presencia del turismo. Conclusiones. El medio urbano se caracteriza por elementos que estimulan el consumo de alcohol y su distribución es desigual, muy influida por las actividades orientadas al turismo. Mejorar la regulación de su promoción, disponibilidad y consumo en el espacio público puede contribuir a cambiar su imagen social y disminuir su uso.

Individual and contextual factors related to binge drinking among adolescents in Spain: a multilevel approach. / Factores individuales y contextuales relacionados con el binge drinking en adolescentes españoles: un enfoque multinivel.

The aim of this study was to estimate the prevalence of binge drinking by regions in Spain and assess the effect of individual and contextual factors related to this drinking pattern in adolescents. A cross-sectional study was performed with data from the 2014 Spanish School Survey on Drug Use (ESTUDES) in students aged 14-18 years (N = 34,259). The outcome was binge drinking in adolescents during the last 30 days. Individual independent variables were socioeconomic variables and variables related to access to alcohol and its availability. Contextual variables consisted of adult alcohol consumption, public policies on alcohol, and socioeconomic factors. Multilevel Poisson regression models with robust variance were estimated, obtaining prevalence ratios (PR) and their 95% confidence intervals.  The results showed that the prevalence of youth binge drinking by region of residence was similar for both sexes (r = 0.72). At the individual level, binge drinking was mainly associated with the perception of easy access to alcohol (PR: 1.38; 95% CI: 1.23-1.55), consumption in open areas [(PR: 3.82; 95% CI: 3.44-4.24) < once a month and (PR: 6.57; 95% CI: 5.85-7.37) ≥ once a month], at least one parent allowing alcohol consumption (PR: 1.42; 95% CI: 1.37-1.47), and receiving >30 euros weekly (PR :1.51; 95% CI: 1.37-1.67). Contextual variables were not associated with youth binge drinking when individual variables were considered. In conclusion, youth binge drinking was associated with individual variables related to high alcohol accessibility and availability, regardless of contextual variables. These variables explained the variability in binge drinking among Spanish regions.

El objetivo de este estudio era estimar la prevalencia de binge drinking por provincias en España y estimar el efecto de variables individuales y contextuales relacionadas con dicho consumo en adolescentes españoles. Se realizó un estudio transversal con datos de la Encuesta sobre uso de drogas en Enseñanzas Secundarias en España (ESTUDES 2014) a estudiantes de 14 a 18 años (N = 34.259). La variable dependiente fue binge drinking en adolescentes durante los últimos 30 días. Las variables independientes individuales fueron variables socioeconómicas y variables relacionadas con el acceso y la disponibilidad de alcohol. Las variables contextuales fueron el consumo de alcohol en adultos, políticas públicas relacionadas con el alcohol y factores socioeconómicos. Se ajustaron modelos de regresión de Poisson multinivel con variancia robusta, obteniendo razones de prevalencia (RP) y sus intervalos de confianza al 95%. Los resultados muestran que la prevalencia de binge drinking en estudiantes españoles en función de la provincia era similar para ambos sexos (r = 0,72). A nivel individual, el binge drinking se asociaba principalmente a una percepción de acceso fácil al alcohol (RP: 1,38; IC 95%: 1,23-1,55), a su consumo en zonas abiertas [(RP: 3,82; IC 95%: 3,44-4,24) < una vez al mes y (RP: 6,57; IC 95%: 5,85-7,37) ≥ una vez al mes], a tener uno de los dos padres que permite beber (RP: 1,42; IC 95%: 1,37-1,47), y a disponer de más de 30 euros semanales (RP: 1,51; IC 95%: 1,37-1,67). Las variables contextuales no se asociaban al binge drinking cuando se consideraban las variables individuales. En conclusión, el binge drinking se asociaba con variables individuales relacionadas con una alta accesibilidad y disponibilidad de alcohol independientemente de las variables contextuales. Estas variables explicaban la variabilidad de el binge drinking entre las provincias.

Entorno urbano de alcohol: un estudio sobre disponibilidad, promoción y visibilidad del consumo en barrios de Barcelona / The urban environment of alcohol: a study on the availability, promotion and visibility of its use in the neighborhoods of Barcelona

Introducción. Se describe la presencia de alcohol en el espacio público, valorando los establecimientos que lo ofrecen, la publicidad, y los indicios de consumo, como factores que pueden inducir el consumo. Método. Estudio observacional descriptivo basado en un muestreo por conglomerados con selección bietápica. Se describen los resultados, y se valora la asociación espacial entre variables. Resultados. En las 20 secciones censales estudiadas se identificaron 306 establecimientos que ofrecían bebidas alcohólicas: 204 de venta y consumo y 102 de venta sin consumo, básicamente supermercados y comercio alimentario. Su distribución territorial fue desigual, concentrada en dos distritos céntricos. Se identificaron 72 elementos de promoción y publicidad destacando el patrocinio de actividades musicales. Se observan elementos promocionales vinculados a los locales de venta y consumo, sobre todo en sus terrazas. Se detectaron cinco personas realizando venta ambulante o promoción del consumo en el casco antiguo. En cada franja horaria se apreciaron entre 39 y 51 indicios de consumo en la vía pública (mayoritariamente envases de cerveza abandonados), más frecuentes de noche y en el casco antiguo. Hay una asociación entre la presencia de establecimientos que ofrecen alcohol y la de elementos de publicidad. No se aprecia relación entre estas variables y los indicios de consumo en el espacio público; éstos se concentran en el casco antiguo, con mayor presencia del turismo. Conclusiones. El medio urbano se caracteriza por elementos que estimulan el consumo de alcohol y su distribución es desigual, muy influida por las actividades orientadas al turismo. Mejorar la regulación de su promoción, disponibilidad y consumo en el espacio público puede contribuir a cambiar su imagen social y disminuir su uso

Introduction. This paper describes the presence of alcohol in the public space, assessing establishments that offer it, its advertising, and signs of consumption, as factors that may influence its consumption. Method. Descriptive observational study based on cluster sampling with two-step selection. Results are described, and the spatial association between variables is assessed. Results. In the 20 census tracts studied, 306 premises were identified that offered alcoholic beverages: 204 were on-premises and 102 were off-premises, mainly supermarkets and food retail stores. Their spatial distribution was uneven, concentrated in two central districts. We identified 72 publicity items, mostly sponsorship of musical events. There were many promotional items linked to on- premises, especially in their terraces. Five people were detected promoting consumption or selling alcohol in the Old Town. In each time slot, between 39 and 51 signs of consumption on the public space were observed (mostly abandoned beer cans), more frequent at night and in the Old Town. There is an association between the presence of establishments that offer alcohol and advertising. There is no relationship between these variables and signs of consumption in the public space; these are concentrated in the Old Town, which has greater presence of tourism. Conclusions. The urban environment is characterized by elements that stimulate alcohol use and its distribution is uneven, with a strong influence of tourism-related activities. Further regulation of alcohol promotion, availability and consumption in the public space may change its social image and decrease its use

Factores individuales y contextuales relacionados con el binge drinking en adolescentes españoles: un enfoque multinivel / Individual and contextual factors related to binge drinking among adolescents in Spain: a multilevel approach

El objetivo de este estudio era estimar la prevalencia de binge drinking por provincias en España y estimar el efecto de variables individuales y contextuales relacionadas con dicho consumo en adolescentes españoles. Se realizó un estudio transversal con datos de la Encuesta sobre uso de drogas en Enseñanzas Secundarias en España (ESTUDES 2014) a estudiantes de 14 a 18 años (N = 34.259). La variable dependiente fue binge drinking en adolescentes durante los últimos 30 días. Las variables independientes individuales fueron variables socioeconómicas y variables relacionadas con el acceso y la disponibilidad de alcohol. Las variables contextuales fueron el consumo de alcohol en adultos, políticas públicas relacionadas con el alcohol y factores socioeconómicos. Se ajustaron modelos de regresión de Poisson multinivel con variancia robusta, obteniendo razones de prevalencia (RP) y sus intervalos de confianza al 95%. Los resultados muestran que la prevalencia de binge drinking en estudiantes españoles en función de la provincia era similar para ambos sexos (r = 0,72). A nivel individual, el binge drinking se asociaba principalmente a una percepción de acceso fácil al alcohol (RP: 1,38; IC 95%: 1,23-1,55), a su consumo en zonas abiertas [(RP: 3,82; IC 95%: 3,44-4,24) < una vez al mes y (RP: 6,57; IC 95%: 5,85-7,37) ≥ una vez al mes], a tener uno de los dos padres que permite beber (RP: 1,42; IC 95%: 1,37-1,47), y a disponer de más de 30 euros semanales (RP: 1,51; IC 95%: 1,37-1,67). Las variables contextuales no se asociaban al binge drinking cuando se consideraban las variables individuales. En conclusión, el binge drinking se asociaba con variables individuales relacionadas con una alta accesibilidad y disponibilidad de alcohol independientemente de las variables contextuales. Estas variables explicaban la variabilidad de el binge drinking entre las provincias

The aim of this study was to estimate the prevalence of binge drinking by regions in Spain and assess the effect of individual and contextual factors related to this drinking pattern in adolescents. A cross-sectional study was performed with data from the 2014 Spanish School Survey on Drug Use (ESTUDES) in students aged 14-18 years (N = 34,259). The outcome was binge drinking in adolescents during the last 30 days. Individual independent variables were socioeconomic variables and variables related to access to alcohol and its availability. Contextual variables consisted of adult alcohol consumption, public policies on alcohol, and socioeconomic factors. Multilevel Poisson regression models with robust variance were estimated, obtaining prevalence ratios (PR) and their 95% confidence intervals. The results showed that the prevalence of youth binge drinking by region of residence was similar for both sexes (r = 0.72). At the individual level, binge drinking was mainly associated with the perception of easy access to alcohol (PR: 1.38; 95% CI: 1.23-1.55), consumption in open areas [(PR: 3.82; 95% CI: 3.44-4.24) < once a month and (PR: 6.57; 95% CI: 5.85-7.37) ≥ once a month], at least one parent allowing alcohol consumption (PR: 1.42; 95% CI: 1.37- 1.47), and receiving >30 euros weekly (PR :1.51; 95% CI: 1.37-1.67). Contextual variables were not associated with youth binge drinking when individual variables were considered. In conclusion, youth binge drinking was associated with individual variables related to high alcohol accessibility and availability, regardless of contextual variables. These variables explained the variability in binge drinking among Spanish regions

A population based perspective of twenty years of specialized ambulatory treatment for alcohol use disorders in publicly financed clinics. Barcelona 1996-2015.

OBJECTIVE: To provide information on persons treated for alcohol use disorders (AUD) over 20 years in a large city in a Southern European country and its trends, adding knowledge on the frequency of treatment from a population perspective. METHODS: This is a study of the number of annual admissions to ambulatory addiction treatment centers funded by the public sector in Barcelona (Catalonia, Spain) for the years 1996-2015. Descriptive analyses of AUD admissions were conducted, comparing changes in the number of patients entering treatment by different independent variables across periods. For city residents, sex and age-specific population annual treatment initiation rates were estimated. RESULTS: The number of ambulatory admissions to AUD treatment increased over the study period. There were about 2100 treatment admissions per year in 2011-2015, of which one fourth were women. About half of these patients had never been treated before for any substance use disorder. Annual rates of treatment initiation among city residents were 208 and 68 per 100,000 people aged 15 and older for men and women respectively, almost the double among 45-54 years old citizens. Rates of total AUD treatment admission increased moderately, but declined among younger adult men. CONCLUSIONS: These figures provide a basic population-based estimation for formal AUD treatment use in a Southern European urban setting with services available free of charge. The development of ambulatory publicly funded addiction centers may have improved access to treatment for people with AUD. age-related changes in treatment admissions may either be related to trends in the population pattern of drinking or to changes in the city demographics.

Long-Term Opioid Agonist Treatment Participation after First Treatment Entry is Similar across 4 European Regions but Lower in Non-Nationals.

Heroin users in opioid agonist treatment (OAT) show markedly reduced heroin consumption, less crime and a lower mortality rate. However, the extent of long-term OAT participation over subsequent treatment episodes remains unclear. We analysed the annual proportion of patients in treatment (at least 1 day) since the start of first OAT in 4 European regions: Barcelona (BA) 1996-2012: 8,602 patients; Czech -Republic (CZ) 2000-2014: 4,377 patients; Netherlands (NL) 1994-2014: 33,235 patients, Zurich (ZU) 1992-2015: 11,795. We estimated the long-term decline of treatment need due to mortality or abstinence and also a "nuisance" short-term decline until the equilibrium level of cycling in and out of OAT is reached to obtain the adjusted treatment participation value. The adjusted treatment participation was around 50% (BA: 47.4-51.4%; CZ: 49.8-53.9%; NL: 52.3-54.0%; ZU: 46.4-49.3%), and the annual decline of treatment need was close to 4%. Non-nationals (NL patients with a migrant background) showed substantial lower adjusted treatment participation (rate ratio BA: 0.059-0.343; NL: 0.710-0.751; ZU: 0.681-0.797; CZ: n.a.). Our method may provide a policy-relevant indicator of long-term provision, quality and access to OAT following first treatment.

Violence among illicit drug users recruited in drug treatment facilities. / Violencia en consumidores de drogas ilícitas reclutados en centros específicos de tratamiento.

Illicit drug use is known to be associated with injuries resulting from violence. This study aims to estimate the prevalence of violence, for the last 12 months, in illicit drug users and study the victim-offender overlap, separately by sex. Persons using illicit drugs (502) were recruited in drug treatment facilities. Violence was assessed using four questions for victim and one for perpetrator in the last 12 months. Associations between violence and socio-demographic, substance use, crime and illegal drug market aspects were examined with Poisson regression models. Victimization was reported by 49.6% men and 54.7% women; offending by 36.5% and 27.6%, respectively. Higher prevalence ratios of both victim and offender were observed among participants with marginal income generation activities and alcohol risk use. Victimization was more likely in women using parenteral route and among men with early illegal drug use, illegal polydrug use or history of imprisonment. Offending was more likely among men reporting psychological treatment, early illegal drug use, illegal polydrug use or past imprisonment, and women reporting early illegal drug use or trafficking. Thus, a high prevalence of violence (both victimization and perpetration) was found in illicit drug users, especially among those involved in market activities and crime. Drug treatment facilities should consider assessing for history and signs of violence and promote community health strategies.

El uso ilícito de drogas se ha asociado a lesiones producidas por violencia. Nuestro objetivo es estimar en usuarios de drogas ilícitas, la prevalencia de violencia en los últimos 12 meses y estudiar la superposición víctima-agresor. Se reclutaron personas consumidoras de drogas ilícitas (502) en centros de tratamiento de drogas. La violencia se evaluó mediante cuatro preguntas sobre victimización y una sobre agresión referidas a los últimos 12 meses. Las asociaciones entre violencia y aspectos sociodemográficos, consumo de sustancias, delincuencia y mercado de drogas ilegales se analizaron con modelos de regresión de Poisson. El 49,6% de los hombres y el 54,7% de las mujeres reportaron victimización; la agresión un 36,5% y 27,6%, respectivamente. Se observaron prevalencias elevadas de víctima y de ofensor entre los participantes con actividades marginales de generación de ingresos y con uso de riesgo de alcohol. La victimización fue más probable en las mujeres que usaban vía parenteral y entre los hombres con consumo precoz de drogas ilegales, policonsumo de drogas ilegales y antecedentes penitenciarios. La agresión fue más probable entre los hombres receptores de tratamiento psicológico, consumo precoz de drogas ilegales, policonsumo de drogas ilegales y antecedentes penitenciarios, y entre las mujeres, aquellas que reportaron consumo precoz de drogas ilegales y que habían traficado. Se encontró una alta prevalencia de violencia en los usuarios de drogas ilícitas, especialmente entre aquellos involucrados en actividades de mercado y delincuencia. Los centros de tratamiento de drogas deberían considerar evaluar los antecedentes y los signos de violencia, y promover estrategias de salud comunitaria.

Differences between men and women in substance use: the role of educational level and employment status / Diferencias entre hombres y mujeres en el consumo de sustancias: el rol del nivel educativo y la situación laboral

Objective: To determine differences between men and women in hazardous drinking, heavy cannabis use and hypnosedative use according to educational level and employment status in the economically active population in Spain. Method: Cross-sectional study with data from 2013 Spanish Household Survey on Alcohol and Drugs on individuals aged 25-64 [n=14,113 (women=6,171; men=7,942)]. Dependent variables were hazardous drinking, heavy cannabis use and hypnosedative consumption; the main independent variables were educational level and employment situation. Associations between dependent and independent variables were calculated with Poisson regression models with robust variance. All analyses were stratified by sex. Results: Hazardous drinking and heavy cannabis use were higher in men, while women consumed more hypnosedatives. The lower the educational level, the greater the gender differences in the prevalence of this substances owing to different consumption patterns in men and women. While men with a lower educational level were higher hazardous drinkers [RII=2.57 (95%CI: 1.75-3.78)] and heavy cannabis users [RII=3.03 (95%CI: 1.88-4.89)] compared to higher educational level, in women the prevalence was the same. Women with a lower education level and men with a higher education level had higher hypnosedative consumption. Unemployment was associated with increased heavy cannabis use and hypnosedative use in both women and men and with lower hazardous drinking only in women. Conclusions: There are differences between men and women in the use of psychoactive substances that can be explained by the unequal distribution of substance use in them according to educational level. Unemployment was associated with substance use in both men and women (AU)

Objetivo: Determinar las diferencias entre hombres y mujeres en cuanto a consumo de riesgo de alcohol, de cánnabis y en el consumo de hipnosedantes según el nivel educativo y la situación laboral en la población activa española. Métodos: Estudio transversal con datos de la Encuesta Domiciliaria sobre Alcohol y Drogas en España (2013) de personas de 25-64 años de edad (n=14.113 [mujeres=6.171; hombres=7.942]). Las variables dependientes fueron consumo de riesgo de alcohol, consumo de cánnabis y consumo de hipnosedantes; las principales independientes fueron el nivel de estudios y la situación laboral. Para estimar la asociación entre variables dependientes e independientes se calcularon modelos de regresión de Poisson con varianza robusta. Todos los análisis se estratificaron por sexo. Resultados: Los hombres tenían mayor consumo de riesgo de alcohol y cánnabis, mientras que las mujeres consumían más hipnosedantes. A menor nivel de estudios, mayores diferencias de sexo en el consumo de estas sustancias. Esto fue debido al patrón distinto de mujeres y hombres. Mientras los hombres con un menor nivel de estudios tenían mayor consumo de riesgo de alcohol (RII=2,57; IC95%: 1,75-3,78) y cánnabis (RII=3,03; IC95%: 1,88-4,89), en comparación con los de un mayor nivel de estudios, la prevalencia en las mujeres era la misma. Las mujeres con menor nivel de estudios y los hombres con mayor nivel de estudios consumían más hipnosedantes. La desocupación se asociaba a un mayor consumo de riesgo de cánnabis y de hipnosedantes tanto en las mujeres como en los hombres, y a un menor consumo de riesgo de alcohol solo en las mujeres. Conclusiones: Existen diferencias entre los hombres y las mujeres en el consumo de sustancias psicoactivas. Estas diferencias pueden explicarse por la desigual distribución del consumo de sustancias en ambos sexos según el nivel de estudios. La desocupación se asociaba al consumo de sustancias tanto en los hombres como en las mujeres (AU)

Differences in mortality in a cohort of cocaine use disorder patients with concurrent alcohol or opiates disorder.

AIMS: To study mortality in a cohort of cocaine use disorder patients, and compare results in those with concurrent alcohol or opiates disorder. DESIGN, SETTING AND PARTICIPANTS: A cohort of 10 539 cocaine use disorder individuals entering drug treatment in public out-patient centres in the city of Barcelona was followed from 1997 to 2011. Participants were divided at baseline into three groups: those with only cocaine use disorder (CUD), those with cocaine and alcohol use disorder but not opioid (CAUD) and those with cocaine and opioid use disorder (COUD). Mortality was assessed through the Spanish National Mortality Register. MEASUREMENTS: Crude mortality rates (CMR), standardized mortality ratios (SMR) and rate ratios (RR) were calculated for each group. A multivariable Cox regression model was fitted to obtain adjusted mortality hazard ratios (aHR) of CAUD and COUD with respect to CUD. Specific mortality causes were also examined. FINDINGS: The total of 716 deaths registered resulted in a CMR = 6.0/1000 person-years (PY); 95% confidence interval (CI) = 5.1-7.0 for CUD, CMR = 5.8/1000 PY (95% CI = 4.9-6.7) for CAUD and CMR = 20.7/1000 PY (95% CI = 18.8-22.8) for COUD, with no significant differences among sexes. Compared with the general population, mortality was four times higher (SMR = 4.1, 95% CI = 3.5-4.8) among CUD, more than three times among CAUD (SMR = 3.4, 95% CI = 2.9-3.9) and more than 10 times among COUD (SMR = 11.6, 95% CI = 10.5-12.8), being always higher in women. External injuries, led by overdose, accumulated the biggest percentage of deaths among the three groups, but infectious diseases showed the highest excess mortality. Some differences regarding causes of death were observed between the three groups. CONCLUSIONS: Mortality risk and excess mortality are significantly greater among those with cocaine and opiates use disorder than among people with only cocaine use disorder or cocaine and alcohol use disorder.

Cancer and Alcohol Consumption in People Aged 50 Years or More in Europe.

AIMS: To estimate the prevalence of hazardous drinking in individuals aged 50 and older who had or had had cancer in 17 European countries and Israel and to analyze the factors associated with their consumption. METHODS: Cross-sectional study based on data from 2011 to 2013 SHARE surveys. A total of 69,509 individuals aged 50 or more from 17 European countries and Israel participated in the study. Prevalence of hazardous drinking in people with cancer was estimated (adapting the SHARE questionnaire to the AUDIT-C). To ascertain whether type of cancer or time since diagnosis were associated with hazardous drinking, Poisson regression models with robust variance were estimated, obtaining prevalence ratios (PR). RESULTS: Overall, 5.4% of participants reported having been diagnosed with cancer. Prevalence of hazardous drinking in people with cancer was 18% in women and 23% in men. After adjusting for various socioeconomic and health variables, no significant differences were observed between hazardous drinking and type of cancer [PR = 0.99 (95% confidence interval (95% CI) = 0.83-1.17) in people with alcohol-related cancers compared to non-alcohol related cancers] and time since diagnosis [PR = 1.01 (95% CI = 0.82-1.25) in people with a cancer diagnosed >5 years ago compared to those diagnosed ≤5 years ago]. Significant differences were found between hazardous drinking and smoking status and self-perceived health. CONCLUSION: In total, 20% of people diagnosed with cancer were hazardous drinkers, despite the known relationship between alcohol use and a worse prognosis of the disease and an increased likelihood of recurrence. SHORT SUMMARY: Overall, 20% of people diagnosed with cancer were hazardous drinkers. There were no significant differences in the prevalence of hazardous drinking depending on the type of cancer (alcohol-related versus non-alcohol related cancers). Highest prevalence of hazardous drinking in people with cancer is found in smokers and people with good self-perceived health.

Effect of ageing and time since first heroin and cocaine use on mortality from external and natural causes in a Spanish cohort of drug users.

BACKGROUND: We aimed to assess the effect of ageing and time since first heroin/cocaine use on cause-specific mortality risk and age disparities in excess mortality among heroin (HUs) and cocaine users (CUs) in Spain. METHODS: A cohort of 15,305 HUs and 11,905 CUs aged 15-49 starting drug treatment during 1997-2007 in Madrid and Barcelona was followed until December 2008. Effects of ageing and time since first heroin/cocaine use were estimated using a competing risk Cox model and the relative and absolute excess mortality compared to the general population through directly age-sex standardized rate ratios (SRRs) and differences (SRDs), respectively. RESULTS: Mortality risk from natural causes increased with time since first heroin use, whereas that from overdose declined after having peaked in the first quinquennium. Significant effects of time since first cocaine use were not identified, although fatal overdose risk seemed higher in CUs after five years. Mortality risk from natural causes (HUs and CUs), injuries (HUs), and overdoses (CUs) increased with age, the latter without reaching statistical significance. Crude mortality rates from overdoses and injuries remained very high at age 40-59 among both HUs (595 and 217 deaths/100,000 person-years, respectively) and CUs (191 and 88 deaths/100,000 person-years). SRDs from all and natural causes were much higher at age 40-59 than 15-29 in both HUs (2134 vs. 834 deaths/100,000 person-years) and CUs (927 vs. 221 deaths/100,000 person-years), while the opposite occurred with SRRs. CONCLUSION: The high mortality risk among HUs and CUs at all ages from both external and natural causes, and increased SRDs with ageing, suggest that high-level healthcare and harm reduction services should be established early and maintained throughout the lifetime of these populations.

Differences between men and women in substance use: the role of educational level and employment status.

OBJECTIVE: To determine differences between men and women in hazardous drinking, heavy cannabis use and hypnosedative use according to educational level and employment status in the economically active population in Spain. METHOD: Cross-sectional study with data from 2013 Spanish Household Survey on Alcohol and Drugs on individuals aged 25-64 [n=14,113 (women=6,171; men=7,942)]. Dependent variables were hazardous drinking, heavy cannabis use and hypnosedative consumption; the main independent variables were educational level and employment situation. Associations between dependent and independent variables were calculated with Poisson regression models with robust variance. All analyses were stratified by sex. RESULTS: Hazardous drinking and heavy cannabis use were higher in men, while women consumed more hypnosedatives. The lower the educational level, the greater the gender differences in the prevalence of this substances owing to different consumption patterns in men and women. While men with a lower educational level were higher hazardous drinkers [RII=2.57 (95%CI: 1.75-3.78)] and heavy cannabis users [RII=3.03 (95%CI: 1.88-4.89)] compared to higher educational level, in women the prevalence was the same. Women with a lower education level and men with a higher education level had higher hypnosedative consumption. Unemployment was associated with increased heavy cannabis use and hypnosedative use in both women and men and with lower hazardous drinking only in women. CONCLUSIONS: There are differences between men and women in the use of psychoactive substances that can be explained by the unequal distribution of substance use in them according to educational level. Unemployment was associated with substance use in both men and women.

Is systematic training in opioid overdose prevention effective?

The objectives were to analyze the knowledge about overdose prevention, the use of naloxone, and the number of fatal overdoses after the implementation of Systematic Training in Overdose Prevention (STOOP) program. We conducted a quasi-experimental study, and held face-to-face interviews before (n = 725) and after (n = 722) implementation of systematic training in two different samples of people who injected opioids attending harm reduction centers. We asked participants to list the main causes of overdose and the main actions that should be taken when witnessing an overdose. We created two dependent variables, the number of (a) correct and (b) incorrect answers. The main independent variable was Study Group: Intervention Group (IG), Comparison Group (CG), Pre-Intervention Group With Sporadic Training in Overdose Prevention (PREIGS), or Pre-Intervention Group Without Training in Overdose Prevention (PREIGW). The relationship between the dependent and independent variables was assessed using a multivariate Poisson regression analysis. Finally, we conducted an interrupted time series analysis of monthly fatal overdoses before and after the implementation of systematic program during the period 2006-2015. Knowledge of overdose prevention increased after implementing systematic training program. Compared to the PREIGW, the IG gave more correct answers (IRR = 1.40;95%CI:1.33-1.47), and fewer incorrect answers (IRR = 0.33;95%CI:0.25-0.44). Forty percent of people who injected opioids who received a naloxone kit had used the kit in response to an overdose they witnessed. These courses increase knowledge of overdose prevention in people who use opioids, give them the necessary skills to use naloxone, and slightly diminish the number of fatal opioid overdoses in the city of Barcelona.

Adolescent alcohol use and parental and adolescent socioeconomic position in six European cities.

BACKGROUND: Many risk behaviours in adolescence are socially patterned. However, it is unclear to what extent socioeconomic position (SEP) influences adolescent drinking in various parts of Europe. We examined how alcohol consumption is associated with parental SEP and adolescents' own SEP among students aged 14-17 years. METHODS: Cross-sectional data were collected in the 2013 SILNE study. Participants were 8705 students aged 14-17 years from 6 European cities. The dependent variable was weekly binge drinking. Main independent variables were parental SEP (parental education level and family affluence) and adolescents' own SEP (student weekly income and academic achievement). Multilevel Poisson regression models with robust variance and random intercept were fitted to estimate the association between adolescent drinking and SEP. RESULTS: Prevalence of weekly binge drinking was 4.2% (95%CI = 3.8-4.6). Weekly binge drinking was not associated with parental education or family affluence. However, weekly binge drinking was less prevalent in adolescents with high academic achievement than those with low achievement (PR = 0.34; 95%CI = 0.14-0.87), and more prevalent in adolescents with >€50 weekly income compared to those with ≤€5/week (PR = 3.14; 95%CI = 2.23-4.42). These associations were found to vary according to country, but not according to gender or age group. CONCLUSIONS: Across the six European cities, adolescent drinking was associated with adolescents' own SEP, but not with parental SEP. Socio-economic inequalities in adolescent drinking seem to stem from adolescents' own situation rather than that of their family.

Changes in alcohol consumption in the 50- to 64-year-old European economically active population during an economic crisis.

Background: The aim was to compare alcohol drinking patterns in economically active people aged 50-64 years before the last economic crisis (2006) and during the crisis (2013). Methods: Cross-sectional study with data from 25 479 economically active people aged 50-64 years resident in 11 European countries who participated in wave 2 or wave 5 of the SHARE project (2006 and 2013). The outcome variables were hazardous drinking, abstention in previous 3 months and the weekly average number of drinks per drinker. The prevalence ratios of hazardous drinking and abstention, comparing the prevalence in 2013 vs. 2006, were estimated with Poisson regression models with robust variance, and the changes in the number of drinks per week with Poisson regression models. Results: The prevalence of hazardous drinking decreased among both men (PR = 0.75; 95%CI = 0.63-0.92) and women (PR = 0.91; 95%CI = 0.72-1.15), although the latter decrease was smaller and not statistically significant. The proportion of abstainers increased among both men (PR = 1.11; 95%CI = 0.99-1.29) and women (PR = 1.18; 95%CI = 1.07-1.30), although the former increase was smaller and not statistically significant. The weekly average number of drinks per drinker decreased in men and women. The decreases in consumption were larger in Italy and Spain. Conclusion: From 2006 to 2013, the amount of alcohol consumed by late working age drinkers decreased in Europe, with more pronounced declines in the countries hardest hit by the economic crisis.

Undiagnosed HIV and Hepatitis C infection in people who inject drugs: From new evidence to better practice.

BACKGROUND: The objective of this study was to estimate the proportion of undiagnosed HIV or Hepatitis C virus (HCV) infection and to assess the risk factors associated with an undiagnosed infection. METHODS: A questionnaire was distributed among people who inject drugs (PWID) in harm reduction centres in Catalonia, Spain 2008-2012 (n=2243). Self-report of HIV and HCV was compared to oral fluid tests to calculate the proportion of undiagnosed infection. Associations of undiagnosed HIV and HCV with age, origin, risk and protective factors of infection and services use were calculated using a Poisson regression model with robust variance. RESULTS: The sensitivity of HIV self-report was 78.5% (75.2%-81.5%) and of HCV was 81.2% (79.1%-83.2%), being lower in younger and foreign-born PWID. Specificity for HCV was 55.9% (51.6%-60.1%). PWID who engaged in infection risk behaviors had lower risk of being undiagnosed. Being foreign-born and younger increased the risk of undiagnosed infection. PWID who had not accessed medical care in the last 6months had 1.46 (1.10-1.93) times more risk of undiagnosed HIV and 1.37 (1.11-1.70) times more risk of undiagnosed HCV. CONCLUSION: Outreach programmes are essential to provide PWID, specially foreign-born and younger PIWD, access to HIV and HCV test.

Hazardous drinking in people aged 50 years or older: a cross-sectional picture of Europe, 2011-2013.

OBJECTIVE: To assess gender and age differences in hazardous drinking and to analyse and compare the factors associated with it in men versus women, and in 50 to 64-year-old versus ≥65-year-old people in Europe. METHODS: Cross-sectional study with data from 65,955 people aged ≥50 years from 18 countries (SHARE project, 2011-2013). The outcome variable, hazardous drinking, was calculated using an adaptation of the AUDIT-C test. Several individual (sociodemographic, life-style and health factors) and contextual variables (country socioeconomic indicators and alcohol policies) were analysed. The prevalence of hazardous drinking was estimated by each exposure variable. To estimate associations, multilevel Poisson regression models with robust variance were fit, yielding prevalence ratios and their 95% confidence intervals (95%CI). RESULTS: Overall, the prevalence of hazardous drinking was 21.5% (95%CI = 21.1-22.0), with substantial differences between countries. The proportion of hazardous drinking was higher in men than in women [26.3%(95%CI = 25.6-27.1); 17.5%(95%CI = 17.0-18.0), respectively], as well as in middle-aged people than in older people [23.6%(95%CI = 23.0-24.3); 19.2%(95%CI = 18.6-19.8), respectively]. At the individual level, associations were found for migrant background, marital status, educational level, tobacco smoking, depression and self-perceived health. At the contextual level, hazardous drinking was associated with gender inequalities in society (only in women) and alcohol advertising regulations (both genders). CONCLUSIONS: One in five people aged ≥50 years in the countries studied is a hazardous drinker, with large differences by countries, gender and age group. Interventions and policies aimed at preventing or reducing alcohol use in this population should account for country, gender and age differences, as well as individual characteristics. Copyright © 2016 John Wiley & Sons, Ltd.

Assessing gender disparities in excess mortality of heroin or cocaine users compared to the general population.

BACKGROUND: Previous analyses of excess mortality in drug users compared with the general population have almost always been based on mortality ratios, reporting much higher figures in women than men. This study tests the hypothesis that being a heroin or cocaine user adds more death risk in women than men in Spain. METHODS: A retrospective cohort of 15,305 heroin users (HUs) and 11,905 cocaine users (CUs) aged 15-49 starting drug treatment in 1997-2007 was recruited in Spain and followed until December 2008 to determine vital status and cause of death. Excess mortality in men and women compared to the general population was assessed with directly age-standardized rate ratios (SRRs) and differences (SRDs). RESULTS: SRR was significantly higher in women than men for all causes (14.7 vs. 9.4), natural causes (8.7 vs. 6.2), overdose (331.6 vs. 163.9) and other external causes (46.9 vs. 11.8) among HUs; and for overdose (170.8 vs. 40.5) and other external causes (21.0 vs. 4.7) among CUs. However, the opposite happened with SRD for all causes (1294 vs. 1845 deaths/100,000 person-years), natural causes (675 vs. 1016 deaths/100,000 person-years) and overdose (331 vs. 619 deaths/100,000 person-years) among HUs, while no significant SRD gender disparities were observed among CUs. CONCLUSION: Compared with the general population, being a heroin user adds greater absolute risk in men than women, but this does not happen with cocaine users. Similar results would likely have been found in most published cohort studies if this indicator had been used; the exclusive use of relative indices of disparity as in previous meta-analysis can be extremely misleading.